Focus on Basal Cell Carcinoma.pdfVIP

Hindawi Publishing Corporation Journal of Skin Cancer Volume 2011, Article ID 328615, 5 pages doi:10.1155/2011/328615 Review Article Focus on Basal Cell Carcinoma Venura Samarasinghe,1, 2 Vishal Madan,1, 2 and John T. Lear1, 2 1 Manchester Royal Infirmary, Central Manchester and Manchester Childrens’ Hospital NHS Trust, Oxford Road, Manchester M13 9WL, UK 2 The Dermatology Centre, Salford Royal Hospital NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK Correspondence should be addressed to Venura Samarasinghe, venuras1@ Received 1 July 2010; Accepted 10 August 2010 Academic Editor: Arash Kimyai-Asadi Copyright © 2011 Venura Samarasinghe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Nonmelanoma skin cancers (NMSCs), which include basal and squamous cell cancers are the most common human cancers. BCCs have a relatively low metastatic rate and slow growth and are frequently underreported. Whilst there is a definite role of sunexposure in the pathogenesis of BCC, several additional complex genotypic, phenotypic and environmental factors are contributory. The high prevalence and the frequent occurrence of multiple primary BCC in affected individuals make them an important public health problem. This has led to a substantial increase in search for newer noninvasive treatments for BCC. Surgical excision with predetermined margins remains the mainstay treatment for most BCC. Of the newer non-invasive treatments only photodynamic therapy and topical imiquimod have become established in the treatment of certain BCC subtypes, while the search for other