Gene Expression Profiling on Global cDNA Arrays Gives Hints Concerning Potential Signal Transduction Pathways Involved in Cardiac Fibrosis of Renal Failure.pdfVIP

Comparative and Functional Genomics Comp Funct Genom 2003; 4: 571–583. Published online in Wiley InterScience (). DOI: 10.1002/cfg.347 Primary Research Paper Gene expression profiling on global cDNA arrays gives hints concerning potential signal transduction pathways involved in cardiac fibrosis of renal failure 1 2 2 3 4 Kerstin Amann *, Heidrun Ridinger , Christiane Rutenberg , Eberhard Ritz , Gerhard Mall and Christian Maercker2 1Department of Pathology, University of Erlangen, Krankenhausstr. 8-10, D-91054 Erlangen, Germany 2 Resource Center for Genome Research, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany 3Department of Internal Medicine, University of Heidelberg, Bergheimerstrasse 56a, 69115 Heidelberg, Germany 4 Department of Pathology, Grafenstrasse 9, 64283 Darmstadt, Germany *Correspondence to: Abstract Kerstin Amann, Department of Pathology, University of Cardiac remodelling with interstitial fibrosis in renal failure, which so far is only ¨ poorly understood on the molecular level, was investigated in the rat model by a global Erlangen-Nurnberg, Krankenhausstrasse 8-10, gene expression profiling analysis. Sprague–Dawley rats were subjected to subtotal D-91054 Erlangen, Germany. nephrectomy (SNX) or sham operation (sham) and followed for 2 and 12 weeks, E-mail: respectively. Heart-specific gene expression profiling, with RZPD Rat Unigene-1 kerstin.amann@patho.imed.uni- cDNA arrays containing about 27 000 gene and EST sequences revealed substantial erlangen.de changes in gene expression in SNX compared to sham animals. Motor protein genes,