Hemoglobin A1C Percentage in Nonhuman Primates A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation.pdfVIP
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Hemoglobin A1C Percentage in Nonhuman Primates A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation.pdf
Hindawi Publishing Corporation
Journal of Transplantation
Volume 2011, Article ID 965605, 8 pages
doi:10.1155/2011/965605
Research Article
Hemoglobin A1C Percentage in Nonhuman Primates: A Useful
Tool to Monitor Diabetes before and after Porcine Pancreatic Islet
Xenotransplantation
Marco Marigliano,1, 2 Anna Casu,1, 3 Suzanne Bertera,1 Massimo Trucco,1 and Rita Bottino1
1 Division of Immunogenetics, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, 4401 Penn Avenue,
Pittsburgh, PA 15224, USA
2 Regional Center of Pediatric Endocrinology and Diabetology, “G. Salesi” Hospital, Via Corridoni 11, 60121 Ancona, Italy
3 Diabetes Unit, Department of Medicine, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT),
Via Ernesto Tricomi, 1 90127 Palermo, Italy
Correspondence should be addressed to Rita Bottino, rib16@
Received 31 December 2010; Accepted 24 February 2011
Academic Editor: Diego Cantarovich
Copyright © 2011 Marco Marigliano et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Non-human primates (NHPs) are a very valuable experimental model for diabetes research studies including experimental
pancreatic islet transplantation. In particular NHPs are the recipients of choice to validate pigs as possible source of pancreatic
islets. The aim of this study was to quantify glycated hemoglobin percentage in NHPs and to assess whether changes in values reflect
the metabolic trends after diabetes induction and islet transplantation. Sera from 15 NHPs were analyzed. 9 NHPs were rendered
diabetic with streptozotocin (STZ), and 3 of them rece
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