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Identification of a Core Set of Genes That Signifies Pathways Underlying Cardiac Hypertrophy.pdf
Comparative and Functional Genomics
Comp Funct Genom 2004; 5: 459–470.
Published online in Wiley InterScience (). DOI: 10.1002/cfg.428
Research Article
Identification of a core set of genes that
signifies pathways underlying cardiac
hypertrophy
1 2 3 1 4
Claes C. Strøm , Mogens Kruhøffer , Steen Knudsen , Frank Stensgaard-Hansen , Thomas E. N. Jonassen ,
2 1 1
Torben F. Ørntoft , Stig Haunsø and Søren P. Sheikh *
1CHARC (Copenhagen Heart Arrhythmia Research Center), Department of Medicine B, H : S Rigshospitalet, University of Copenhagen
Medical School, 2100 Copenhagen, Denmark
2Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Denmark
3Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Kgs, Lyngby, Denmark
4 Department of Pharmacology, Copenhagen University, 2100 Copenhagen, Denmark
*Correspondence to: Abstract
Søren P. Sheikh, Lab. Mol. Card.,
Department of Medicine B, H : S Although the molecular signals underlying cardiac hypertrophy have been the
Rigshospitalet, University of subject of intense investigation, the extent of common and distinct gene regulation
Copenhagen, 20 Juliane between different forms of cardiac hypertrophy remains unclear. We hypothesized
Mariesvej, DK-2100 that a general and comparative analysis of hypertrophic gene expression, using
Copenhagen, Denmark. microarray technology in multiple models of cardiac hypertrophy, including aortic
E-mail: sheikh@molheart.dk banding, myocardial infarction, an arteriovenous shunt and
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