In Silico Modelling of Treatment-Induced Tumour Cell Kill Developments and Advances.pdfVIP

Hindawi Publishing Corporation Computational and Mathematical Methods in Medicine Volume 2012, Article ID 960256, 16 pages doi:10.1155/2012/960256 Review Article In Silico Modelling of Treatment-Induced Tumour Cell Kill: Developments and Advances Loredana G. Marcu1, 2, 3 and Wendy M. Harriss-Phillips1, 2 1 Department of Medical Physics, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia 2 School of Chemistry and Physics, University of Adelaide, Adelaide, SA 5000, Australia 3 Faculty of Science, University of Oradea, 410087 Oradea, Romania Correspondence should be addressed to Loredana G. Marcu, loredana.marcu@.au Received 14 February 2012; Revised 10 May 2012; Accepted 14 May 2012 Academic Editor: Scott Penfold Copyright © 2012 L. G. Marcu and W. M. Harriss-Phillips. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Mathematical and stochastic computer (in silico) models of tumour growth and treatment response of the past and current eras are presented, outlining the aims of the models, model methodology, the key parameters used to describe the tumour system, and treatment modality applied, as well as reported outcomes from simulations. Fractionated radiotherapy, chemotherapy, and combined therapies are reviewed, providing a comprehensive overview of the modelling literature for current modellers and radiobiologists to ignite the interest of other computational scientists and health professionals of the ever evolving and clinically relevant field of tumour modelling. 1. The Need for In Silico Modelling followup, complex data analysis, and interpretati