Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos.PDFVIP

Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos Simon Kidd,1 Toby Lieber, 1 and Michael W. Young2 Laboratory of Genetics, The Rockefeller University, New York, New York 10021-6399 USA Notch, a transmembrane protein found in a wide range of organisms, is a component of a pathway that mediates cell-fate decisions that involve intercellular communication. In this paper, we show that in Drosophila melanogaster, Notch (N) is processed in a ligand-dependent fashion to generate phosphorylated, soluble intracellular derivatives. Suppressor o