Mg2+ Modulates Voltage-Dependent Activation in Ether-à-Go-Go Potassium Channels by Binding between Transmembrane Segments S2 and S3.PDFVIP

Mg2 Modulates Voltage-dependent Activation in Ether-à-go-go Potassium Channels by Binding between Transmembrane Segments S2 and S3 William R. Silverman, Chih-Yung Tang, Allan F. Mock, Kyung-Bong Huh, and Diane M. Papazian From the Department of Physiology and Molecular Biology Institute, University of California Los Angeles School of Medicine, Los Angeles, California 90095-1751 abstract Extracellular Mg2 directly modulates voltage-dependent activation in ether-à-go-go (eag) potassium channels, slowing the kinetics of ionic an