原创力文档Nucleolin, a Shuttle Protein Promoting Infection of Human Monocytes by Francisella tularensis.PDFVIP
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Nucleolin, a Shuttle Protein Promoting Infection of Human Monocytes by Francisella tularensis.PDF
Nucleolin, a Shuttle Protein Promoting Infection of
Human Monocytes by Francisella tularensis
Monique Barel1,2*, Karin Meibom1,2, Alain Charbit1,2
´ ´ ´
1 Universite Paris Descartes, Faculte de Medecine Necker Enfants-Malades, Paris, France, 2 INSERM U1002, Unit of Pathogenesis of Systemic Infections, Paris, France
Abstract
Background: Francisella tularensis is a highly virulent facultative intracellular bacterium, disseminating in vivo mainly within
host mononuclear phagocytes. After entry into macrophages, F. tularensis initially
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