Partial Rescue of Retinal Function in Chronically Hypoglycemic Mice.PDFVIP

Retinal Cell Biology Partial Rescue of Retinal Function in Chronically Hypoglycemic Mice Yumiko Umino,1,2 Nicolas Cuenca,2,3 Drew Everhart, 1,2 Laura Fernandez-Sanchez,3 Robert B. Barlow, 1,4 and Eduardo Solessio1 PURPOSE. Mice rendered hypoglycemic by a null mutation in the (Invest Ophthalmol Vis Sci. 2012;53:915–923) DOI:10.1167/ glucagon receptor gene Gcgr display late-onset retinal degen- iovs.11-8787 eration and loss of retinal sensitivity. Acute hyperglycemia induced by dextrose ingestion does not restore their retinal