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2016-03-05 发布于广东
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mechanics of cell adhesion evolution, stability and strength.ppt

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mechanics of cell adhesion evolution, stability and strength

* Numerical scheme for finding the solution Since filament growth is coupled with the cargo motion, an iterative scheme was constructed to determine the solution. The closed form solution from GEBR model is used to evaluate filament forces at different locations. * Symmetric perturbation in polymerization Assume Propelling force distribution among filaments arranged in a 5 X 5 array Upadhyaya et al., PNAS, (2003) Negative propelling forces can be generated by the inner part of the tail if polymerization there is much slower than that at the outer portion of the tail. * Asymmetric perturbation in polymerization In this case, let Filament forces also become asymmetric A net moment will be generated causing the cargo to move in circles Radius of curvature as a function of perturbation magnitude * Spinning of Listeria Moving Listeria actually spins along its long-axis Robbins and Theriot, Current Biology, (2003) It has been proposed that spinning is essential for the generation of different Listeria trajectories. Shenoy et al., PNAS, (2007) * Generation of a tangential force How can the spinning be generated? Consider a more realistic description of the tip – load surface interaction The interaction fore is along direction As such, in addition to a propelling force, a tangential force will also be induced Small deformation * Correlation in filament orientations leads to a torque causing Listeria to spin Notice that the direction of the tangential force depends on filament orientation Random Partially correlated Totally correlated A torque can be generated as Characterize the correlation in filament orientations with a single parameter The spinning angular velocity is * 2-D Listeria motion When confined to move in a plane, say x-y plane. The z component of moment generated by polymerizing filaments is The cargo trajectory can then be determined as: Or Comparison with experimental data * * Conclusions The model can indeed reproduce almost all observed traj