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d-limonene safety and clinical applications
Alternative Medicine Review Volume 12, Number 3 2007
Review Article
D-Limonene:
Safety and Clinical Applications
Jidong Sun, PhD
Introduction
D-limonene (1-methyl-4-(1-methylethenyl)
cyclohexane) is a monocyclic monoterpene (Figure 1)
with a lemon-like odor and is a major constituent in
several citrus oils (orange, lemon, mandarin, lime, and
grapefruit). Because of its pleasant citrus fragrance, d-li-
Abstract monene is widely used as a flavor and fragrance additive
D-limonene is one of the most common terpenes in nature. in perfumes, soaps, foods, chewing gum, and beverages.1
D-limonene is listed in the Code of Federal Regulation
It is a major constituent in several citrus oils (orange, lemon,
as generally recognized as safe (GRAS) for a flavoring
mandarin, lime, and grapefruit). D-limonene is listed
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