血栓心血管基础精要.ppt

Slide * Slide E 1: Targets of Antiplatelet Therapy Platelets possess multiple receptors for pro-aggregatory stimuli including collagen, adenosine diphosphate (ADP) and thrombin on their surface. Binding of the ligands to these receptors triggers a cascade of intracellular signals. Thereby, the activation finally leads to the conversion of the platelet surface glycoprotein IIb/IIIa complex (GP IIb/IIIa) to a binding site for fibrinogen, von Willebrand factor and other adhesion molecules which anchor adjacent platelets into aggregates. Antithrombotic agents target different steps in this casca