John Wiley Sons, Ltd. Treatment of Mice with a Herbal.pdfVIP

PHYTOTHERAPY RESEARCH Phytother. Res. 17, 876–881 (2003) Published online in Wiley InterScience (). DOI: 10.1002/ptr.1142 John Wiley Sons, Ltd. Treatment of Mice with a Herbal Preparation (Mentat) Protects Against Radiation-Induced Mortality Mentat Protects Against Radiation-Induced Mortality Ganesh Chandra Jagetia* and Manjeshwar Shrinath Baliga Department of Radiobiology, Kasturba Medical College, Manipal, India The effect of various doses (0, 5, 10, 20, 40, 80, 100, 120 and 160 mg/kg b. wt.) of 50% ethanolic extract of mentat (a herbal preparation) was studied on the survival of mice exposed to 10 Gy of γγ -radiation. Treat- γγ ment of mice with different doses of mentat consecutively for five days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug treated irra- diated controls. Most of the doses of mentat provided protection against the gastrointestinal (GI) death, however, the highest protection against GI death was observed for 80 mg/kg mentat. This was also true for bone marrow deaths, where the highest number of survivors were observed at 30 days post-irradiation in this group (i.e. 80 mg/kg) when compared with the other doses of mentat. The evaluation of acute toxicity showed that mentat was non-toxic up to a dose of 1.5 g/kg b. wt., where no drug-induced mortality was observed. The LD50 dose of mentat was found to be 1.75 g/kg b. wt. Our study demonstrates that mentat can provide good radioprotection at a dose of 80 mg/ kg, which is far below its t