a ph-responsive cell-penetrating peptide-modified liposomes with active recognizing of integrin αvβ3 for the treatment of melanoma：一种活性识别的ph敏感细胞穿透肽修饰脂质体，用于治疗黑色素瘤.pdfVIP

下载本文档

19
0
约9.68万字
约 13页
2016-03-12 发布于广东
举报
版权申诉

a ph-responsive cell-penetrating peptide-modified liposomes with active recognizing of integrin αvβ3 for the treatment of melanoma：一种活性识别的ph敏感细胞穿透肽修饰脂质体，用于治疗黑色素瘤.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

a ph-responsive cell-penetrating peptide-modified liposomes with active recognizing of integrin αvβ3 for the treatment of melanoma：一种活性识别的ph敏感细胞穿透肽修饰脂质体，用于治疗黑色素瘤

Journal of Controlled Release 217 (2015) 138 –150 Contents lists available at ScienceDirect Journal of Controlled Release journal homepage: www. / locate/jconrel A pH-responsive cell-penetrating peptide-modiﬁed liposomes with active recognizing of integrin αvβ3 for the treatment of melanoma Kairong Shi a, Jianping Li a, Zhonglian Cao b, Ping Yang b, Yue Qiu a, Bo Yang a, Yang Wang a, Yang Long a, Yayuan Liu a, Qianyu Zhang a, Jun Qian b, Zhirong Zhang a, Huile Gao a, Qin He a,⁎ a Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China b School of Pharmacy, Fudan University, Shanghai, China a r t i c l e i n f o a b s t r a c t Article history: The use of pH-responsive cell-penetrating peptides (CPPs) is an attractive strategy for drug delivery in vivo, Received 29 March 2015 however, they still could not actively target to the desired sites. Here, we designed a pH-responsive CPP (TR) Received in revised form 12 August 2015 with the ability of active targeting to integrin α β , which was a tandem peptide consisted of active targeting li- v 3 Accepted 8 September 2015 gand peptide (c(RGDfK)) and pH-responsive CPP (TH). The targeting efﬁciency of TR with integrin was evaluated Available online 12 September 2015 by molecular simulation and docking