abdominal obesity, hypertension, antihypertensive medication use and biochemical recurrence of prostate cancer after radical prostatectomy：前列腺癌根治术后腹型肥胖，高血压，降压药物使用及生化复发.pdf

European Journal of Cancer (2015) 51, 604– 609 A v a i l a b l e a t w w w . s c i e nc e d i r e c t . c o m ScienceDirect jour nal homepage: Abdominal obesity, hypertension, antihypertensive medication use and biochemical recurrence of prostate cancer after radical prostatectomy Kazuhiro Ohwaki a,b,⇑, Fumiyasu Endo a, Kazunori Hattori a a Department of Urology, St. Luke’s International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo 104-8560, Japan b Health Management Center, JCHO Tokyo Shinjuku Medical Center, 5-1 Tsukudo-cho, Shinjuku-ku, Tokyo 162-8543, Japan Received 25 July 2014; received in revised form 19 December 2014; accepted 5 January 2015 Available online 19 January 2015 KEYWORDS Abstract Background: The aim of this study was to determine whether abdominal obesity, Prostate cancer including visceral adipose tissue (VAT) measured by computed tomography and blood pres- Prostatectomy sure (BP) were associated with biochemical recurrence of prostate cancer after prostatectomy. Recurrence Methods: We investigated 283 patients who underwent radical prostatectomy for prostate Hypertension cancer retrospectively. We obtained information on body mass index (BMI), waist circumfer- Antihypertensive agents ence (WC), VAT, BP, antihypertensive drug use, pretreatment prostate-specific antigen levels, Abdominal obesity pathological Gleason scores and postoperative surgical margin status. Hypertension was defined as systolic BP (SBP) P 130 mmHg or diastolic BP P 85 mmHg. Results: Among 283 patients,