aberrant expressions of c-kit and dog-1 in mucinous and nonmucinous colorectal carcinomas and relation to clinicopathologic features and prognosis：在粘液性和非黏液性大肠癌临床病理特征及预后的关系及c-kit蛋白的异常表达.pdf

Annals of Diagnostic Pathology 19 (2015) 335–340 Contents lists available at ScienceDirect Annals of Diagnostic Pathology Aberrant expressions of c-KIT and DOG-1 in mucinous and nonmucinous colorectal carcinomas and relation to clinicopathologic features and prognosis☆,☆☆ Abd Al-Rahman Mohammad Foda, PhD, Mie Ali Mohamed, PhD ⁎ Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt a r t i c l e i n f o a b s t r a c t Keywords: c-KIT and DOG-1 are 2 highly expressed proteins in gastrointestinal stromal tumors. Few studies had investigated Colorectal c-KIT, but not DOG-1, expression in colorectal carcinoma (CRC). This study aims to investigate expressions of c-KIT Mucinous and DOG-1 in colorectal mucinous carcinoma and nonmucinous carcinoma using manual tissue microarray c-KIT technique. In this work, we studied tumor tissue specimens from 150 patients with colorectal mucinous (MA) DOG-1 and nonmucinous adenocarcinoma (NMA). High-density manual tissue microarrays were constructed using modified mechanical pencil tip technique, and immunohistochemistry for c-KIT and DOG-1 was done. We found that aberrant c-KIT expression was detected in 12 cases (8%); 6 cases (4%) showed strong expression. Ab- errant DOG-1 expression was detected in 15 cases (10%); among them, only 4 cases (2.7%) showed strong ex-