氯丙嗪、利培酮阿立哌唑对精神分裂症病人血糖的影响.pdfVIP

氯丙嗪、利培酮、阿立哌唑对精神分裂症病人血糖的影响 摘要 目的：探讨氯丙嗪、利培酮和阿立哌唑三种抗精神病药物对精神分裂症病人血糖的 影响。 方法：将住院精神分裂症病人按所服药物分为氯丙嗪组，利培酮组和阿立哌唑组， 共152例，在治疗前、治疗后1个月、3个月、6个月分别进行一次空腹血糖检测。 结果：氯丙嗪组治疗后6个月与治疗前相比血糖有显著变化(PO．05)；治疗后6个 月氯丙嗪组血糖变化率显著高于利培酮组和阿立哌唑组(PO．05)；利培酮组和阿立 哌唑组治疗前与治疗1月、3月、6月后血糖无明显变化(PO．05)。 结论：长期服用氯丙嗪有升高精神分裂症病人血糖危险，尤其是中老年病人；利培 酮和阿立哌唑对血糖影响较小。 ．． 硕士研究生徐勇(精神病与精神卫生学) 指导教师 于建华主任医师 关键词：精神分裂症：氯丙嗪：利培酮；阿立哌唑：血糖 洲Y…2㈣0墨呈4㈣3洲0川2Ⅷ2 EffectsOf TreatmentOnBloodGlucoseOfPatients Antipsychotics With Schizophrenia Abstract theeffectsof and Oil objective：To explore Chlorpromazine，RisperidoneAripiprazole blood of with glucosepatientsschizophrenia． tothemedication divide152 with Methods：According condition，to in-patient into and schizophreniaChlorpromazine Aripiprazole group，Rispcridonegroup group． Blood onan stomachwasassessedandafter1 glucoseempty prior month，3months，6 monthstreatment． Results：Therewas differencesonblood betweenbeforeandafter significant glucose treatmentof6monthsin treatmentof6months， Chlorpromazinegroup(PO．05)；After therateof ofblood of was change glucoseChlorpromazinegroupsignificantlyhigher than andthe Wasrio Risperidonegroup’S Aripiprazolegroup’s(PO．05)；Theresignificant differencesonblood beforetreatmentaftertreatmentof month between a