癫痫与阻塞性睡呼吸暂停低通气综合征的临床研究.pdfVIP

摘要 摘要 目的：研究癫痫合并阻塞性睡眠呼吸暂停低通气综合征 ObstructiveSleepApnea Hypopnea 讨癫痫治疗的新途径。 脑电图及视频多导睡眠图 PSG 检查，筛选出合并OSAHS的患者组与不合并 OSAHS的患者组。两组进行比较，分别记录两组患者的一般情况 年龄、身高、 体重、病程、ESS评分 、癫痫发作情况 发作频率、常见发作时间、类型 、 脑电图和多导睡眠图指标，比较两组的临床特点和监测结果，对所有数据进行统 计学处理。 结果：共34例患者入选，癫痫合并OSAHS14例，未合并OSAHS20例，两组患 者的年龄、身高、体重、病程无明显差异 P o．05 。两组ESS评分、癫痫发作频 睡眠效率、总睡眠时间、睡眠潜伏期、S1．S4时间、REM潜伏期及时间无明显差 异僻 o．05 ：而呼吸紊乱指数 AnD、平均呼吸暂停时间、平均最低血氧饱和度 Sp02 存在明显差异 P o．05 。 结论：癫痫和OSAHS常常并存，且OSAHS常见于夜间和部分性发作的癫痫患者； OSAHS可加剧癫痫的发作。 关键词：癫痫；阻塞性睡眠呼吸暂停低通气综合征；多导睡眠图 II Abstract ABSTRACT To theclinicalcharacterofthe with and Objectiveinvestigate patientsepilepsy Obstructive the SleepApneaHypopneaSyndrome 0SAHS ，andreciprocal influencebetween and tofindoutthenew tocure EpilepsyOSAHS．Attempt way in patientepilepsy． MethodsThe essential wele∞lectedfrom patients谢廿l epilepsy randomlyJuly 2006toMarch2008todo16-lead into OSAHSand polysomnography PSG ，dividedepilepsypatients诮mgroup withoutOSAHS withthetwo epilepsypatients group．Comparedgroups，recorded the clinical andESS mass，COUl∞ofdisease general material age，bedyheight，bedy of theindex SCOreS ，seizuresituation frequencyseizures，commontime，type and ofEEGand theclinicalcharacterand outcome PSG，then compared谢m supervise ofthetwo alldatastatisticsmethod． groups，disposedby Results34 were 4 winlOSAHSand20 selected,1 patients epilepsypatients epilepsy withoutOSAHS．Thetwo were in similar patients age，bedy groups height，body massandcourseof intwo had different disease P 0．05 ．Patientssignificant groups ESSscoresand of scizur懿inthe frequency epilepsyseizures口 0．05 ．Epilepsy withOSAHS at patients morecommon the epilepsy grouphappened night，and seizures 6／14 wasthan withoutOSAHS ofpartial proportion higherpatients group showedthat 4／20 ．PSG therewasno differencein significant sleep efficiency, total 1-4 and sleeptime，sleep time，REM latency,stage latency Hypopnea andlowestPulse Apnea Index AHI ，averageapneatime，average OxygenSaturation Sp02 hadsignificantdifference P 0．05