基于高密度SNP标记的肉牛人工选择痕迹筛查.pdfVIP

HEREDITAS (Beijing) 2012 10 , 34(10): 1304―1313 ISSN 0253-9772 研究报告 DOI: 10.3724/SP.J.1005.2012.01304 基于高密度SNP 标记的肉牛人工选择痕迹筛查 1,2 2 1 1 1 刘喜冬 , 王志鹏 , 樊惠中, 李俊雅 , 高会江 1. , , , 100193; 2. , 150030 近年来随着遗传改良工作的实施, 人工选择大大提高了肉牛的生产性能并使其遗传基础发生巨大改变。 文章基于Illumina BovineSNP50(54K)和BovineHD(770K) 两款芯片数据, 采用F ST检验方法分析牛群的遗传分化, 并筛查人工选择在牛的基因组留下的印记。通过全基因组范围内的扫描, 共发现 47 104 个“ 离群”位点和 3064 个群体特异的人工选择“候选基因”, 如CLIC5、TG、CACNA2D1、FSHR 等。通过基因注释对基因的生物学过程 和分子功能进行富集分析。文章构建了我国肉牛的全基因组的选择信号图谱, 为深入研究人工选择和理解生物 进化提供线索, 且研究结果也显示人工选择对基因组的影响在牛品种遗传改良中发挥了重要作用。 牛的基因组; 人工选择; 单核苷酸多态性; 基因注释 Artificial selection for cattle based on high-density SNP markers 1,2 2 1 1 1 LIU Xi-Dong , WANG Zhi-Peng , FAN Hui-Zhong , LI Jun-Ya , GAO Hui-Jiang 1. Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture, Beef Cattle Research Center, Institute of Animal Sciences , Chinese Academy of Agricultural Sciences, Beijing 100193, China; 2. College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China Abstract: With the implementation of genetic improvement in recent years, artificial selection has greatly improved beef cattle production performance and its genetic basis has been dramatically changed. In this study, based on the Illumina BovineSNP50 (54K) and BovineHD (770K) BeadChip and the FST value, we analyzed the genetic differentiation of cattle and screened the imprints o