46Cancer资料.pptVIP

Chapter 46 Anticancer Drugs 抗恶性肿瘤药 Organization of Class Principles of Cytotoxic Therapy 1. Killing Dividing Cells 2. Using Combination of Drugs Targets of Cytotoxic Drugs Countering Resistance Tumor Susceptibility,and Cell-Cycle Specificity of Drugs Adverse Effects 1. Bone Marrow 2. Gastrointestinal System Damage to Other Tissues Alkylating Agents Alkylating Agents Antimetabolites Antimetabolite: Methotrexate Antimetabolite: 6-Mercaptopurine Antimetabolite: 5-Fluorouracil Antibiotics Microtubule Inhibitors Microtubule Inhibitors Cellular Growth Factors Hormonal Agents * * anticancer drugs ho