软物质功能材料(刘向阳)3.pdfVIP

Outline •  Introduction: Proteins and the structure determination •  Protein crystallization: challenges and techniques Introduction: Importance of protein crystallization ü Structure of protein (3D): Structural biology and drug design ü Controlled drug delivery: bioavailability ü Bioseparation: recrystallization X-ray Crystallography Introduction: Structural biology and drug design Do you know…? •  100K different proteins in living organisms, built by ~ 20 amino acids. Each with unique structure and bio-functionality. •  Known structure: only less than 1K proteins Introduction: Proteins •  Proteins either achieve all of the cell structure and functions or they make all of the other molecules and structures which give functions to cells. •  Almost all your cells, including skin, hair, and muscles are all made of proteins. Introduction: Type of Proteins •  Globular protein ▫  Enzyme… ▫  Transport… ▫  Storage… ▫  Defense… antibody ▫  … •  Membrane protein ▫  Signal… ▫  Transport… Introduction: Type of Proteins •  Fibril protein ▫  Structural… ▫  … Protein Subunits: The Amino Acids Protein Subunits: The Amino Acids ¡ Each amino acid has a central carbon atom (the  carbon) to which various functional groups are attached Amino Carbox