消翳汤治疗角膜皮下雾状混浊的临床研究.pdfVIP

消翳汤治疗角膜上皮下雾状混浊的临床研究 The Studies Effect of Xiao yi tang on the formation of haze in patients after undergoing LASEK surgery Liu Li (Science of Facial Features of Traditional Chinese Medicine) Directed by Zhang Fengmei Abstract Objective: To observe the prophylaxis and trate effect of Xiao yi tang on the formation of haze in patients after undergoing LASEK surgery. Method: 60cases (116eyes) were randomly divided group A and group B : group A( n = 30cases/58 eyes) were t reated with Fu mei tong eye drops and Xiao yi tang, and group B ( n = 30cases/58 eyes only with Fu mei tong eye drops .The patients were followed regularly to observe UCVA ,intraocular pressure and the haze formation. Result: The haze in group A was slighter than in Group B( P 0.05). Conclusion: The application of Fu mei tong eye drops and Xiao yi tang after LASEK operation could reduce the formation of haze and lower intraocular pressure,yet without toxic effect. Key words: Xiao yi tang ; Keratomileusis ;Laser ;haze 2 前言 前言 准分子激光角膜上皮瓣下磨镶术（laser-assisted subepithelial keratectomy ，LASEK ） 是一种安全有效，精确度高，预测性好，相对更加成熟的治疗近视的手术。LASEK 治 疗高度近视的安全性高，有效性和稳定性强，术后视觉效果好，尤其是对于角膜薄， 近视度数高，准分子激光角膜原位磨镶术（laser in situ keratomileusis, LASIK ）制做角 膜瓣有一定难度的近视患者，既能降低手术风险,又能扩大近视治疗的范围，是较为安 全和首选的手术方式。然而角膜上皮下雾状混浊（haze ）的发生仍是LASEK 术后最主 要的并发症，一旦形成便会导致对比敏感度下降，眩光和雾视，并伴屈光力回退等， 影响患者的视觉质量与远期疗效，故探索预防和治疗haze 的方法，是临床医师亟待解 决的问题，也是眼科界关注的焦点。haze 的发生机制并不十分清楚，大多数学者认为 haze 的形成与角膜组织创伤愈合修复反应有关。 西医学研究表明糖皮质激素，非甾体抗炎药，抗代谢药物，锌制剂，抗氧化剂，纤 溶酶原激活剂，抗纤维化药物，羊膜移植 ，可以抑制 haze 的形成，但是有些还处于 动物试验阶段，目前临床多采用糖皮质激素，但长期应用糖皮质激素会引起眼压升高、 ［］