LPS TLR4 信号通路课件.pptVIP

LPS TLR4 Signal Transduction Pathway Introduction 1. Sepsis(败血症) is a life-threatening condition in which bacterial infection occurs in the bloodstream of an individual. This condition is also referred to as systemic inflammatory response syndrome (SIRS-全身性炎症反应综合征). Introduction 2. Systemic inflammatory response syndrome(SIRS全身性炎症反应综合征) leads to Multiple organ dysfunction syndrome (MODS多器官功能障碍综合征). Introduction 3. Sepsis can be caused due to internal or external infections. Once the microorganisms enter the human body, they have the potential to spread to other parts of the body via blood circulation Introduction 4. It is commonly that bacterial endotoxin such as lipopolysaccharide (LPS) causes sepsis. The real mechanism of sepsis lies in the Toll-like receptors that suppress sepsis caused by tissue injury or endotoxin. When Toll-like receptors initial suppression role is overwhelmed, sepsis ensues. LPS TLR4 pathway 1.TLR Pathway is an ancient innate immune system Toll pathways in Drosophila and mammals LPS TLR4 pathway 2. An introduction of LPS 2.1 As a component of the gram negative cell envelope, It comprises three parts: 1). O antigen (or O polysaccharide) 2). Core oligosaccharide 3). Lipid A 2.2 The lipid A domain is responsible for much of the toxicity of Gram-negative bacteria. LPS TLR4 pathway 3. PAMPs Pathogen associated molecular patterns (LPS) PAMPs are molecules associated with groups of pathogens, that are recognized by cells of the innate immune system. These molecules can be referred to as small molecular motifs conserved within a class of microbes; therefore microbe-associated molecular pattern,MAMP LPS TLR4 pathway 4. PRRs Pattern recognition receptors, are proteins expressed by cells of the innate immune system to identify PAMPs. 3.2 The lipid A domain is responsible for much of the toxicity of Gram-negative bacteria. Toll Like Receptors LPS TLR4 pathway 5.Generalized major signal transduction pathway of TLR4 LPS TLR4 pa