食品和机体中的移动通讯网络_庞广昌.pdfVIP

※专家约稿 食品科学 2010, Vol. 31, No. 21 1 食品与机体中的移动通讯网络 庞广昌，陈庆森，胡志和，谢军波 (天津市食品生物技术重点实验室，天津商业大学生物技术与食品科学学院，天津 300 134) 摘 要：在总结近年来有关食品胃肠黏膜信号通路研究的基础上，根据现代免疫学的研究成果，提出机体中存在 着移动细胞之间的通讯网络的假说，该假说认为：细胞因子网络实际上就是移动通讯网络的信号传递系统；机体 中的移动细胞可以依赖细胞因子，通过自分泌、旁分泌进行局部通讯；通过内分泌进行远距离全局性通讯；通过 和固定细胞之间的信号交流和胃肠道黏膜、神经内分泌系统进行高密度的通讯联系，从而形成一个 “无线”和 “有线”之间相互协调的通讯网络；在这个通讯网络中，细胞通过受体及其信号传递、级联放大系统接受并通过 基因表达与调控定量放大这些细胞信号，从而发挥生命活动；而细胞因子和趋化因子等信号分子则通过循环系统在 固定和移动细胞之间传递信号，分子之间互不干涉，在极低的浓度下通过相应的细胞发挥通讯媒体的作用。作者 通过研究发现：功能性食品正是通过改变这个复杂的通讯网络发挥其生物功能。这一理论和研究方法的建立将有可 能从根本上改变功能性食品如何发挥生物功能的评价方法和标准。 关键词：细胞通讯；细胞因子网络；趋化因子；无线通讯网络；功能性食品 Wireless Communication Networks between Food and Human Body PANG Guang-chang ，CHEN Qing-sen ，HU Zhi-he ，XIE Jun-bo (Tianj in Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianj in University of Commerce, Tianj in 300 134, China) Abstract ：A new hypothesis of cellular wireless communication networks was proposed on the basis of current research achievements in the field of immunology, which were summarized from gastrointestinal mucous receptor pathways of foods. In this hypothesis, cytokine network was a signal transduction sy stem during cell communications. The cells especially for leukocytes can communicate with each other in networks by a manner of paracrine or autocrine. In addition, the cells can also execute long-distance whole communication through the autocrine mode. A coordinated communication network between wireless and wire communications was established through cellular communication between gastrointestinal mucous and neu- roendocrine system. In this communication network, cells accepted gene expression and quantitative reg