血管祖细胞在动脉粥样硬化发病中的作用PPT课件.pptVIP

Accumulation of smooth muscle cells (SMCs) plays a principal role in atherogenesis It generally is believed that neointimal SMCs in vascular lesions originate locally from SMCs of the medial layer. However, several phenomena could not be explained by this hypothesis. Very few articles have documented SMCs migrating across the internal elastic lamina from the media into the subendothelial layer. Blood cells attach to the luminal side of the injured artery prior to the development of neointimal hyperplasia. Neointima could be formed in the absence of medial cells. SMC hyperplasia could be pr