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慢阻肺的炎症反应对糖皮质激素相对不敏感 Barnes PJ.J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):76-85. Tonello A, Poli G. Medical Hypotheses, 2011,76: 358-360. COPD的特点是对糖皮质激素抵抗，即使使用高剂量的糖皮质激素，对COPD患者无法改变的肺功能下降疗效甚微，且对减少COPD加重的疗效很小 Glucocorticoids are the most effective anti-inflammatory therapy for many chronic inflammatory and immune diseases, such as asthma, but are relatively ineffective in other diseases such as chronic obstructive pulmonary disease (COPD) 对许多慢性炎症及免疫性疾病，如哮喘而言，糖皮质激素是最有效的抗炎治疗，但对COPD患者，糖皮质激素相对无效 COPD is characterized by corticosteroid resistance, as even high doses of corticosteroids have a min