白细胞介素-10基因多态性和胃癌恶病质的关系.pdf

白细胞介素-10基因多态性和胃癌恶病质的关系.pdf

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AssociationofInterleukin-10Gene with Cachexiafrom Polymorphism PatientswithGastricCancer Abstract isa that both ObjectiveInterleukin(IL)一10 can stimulateand pleiotropiccytokine the studieshave thatIL-10 suppressinflammatoryresponse.Previousreported production was elevatedincachectic it has confirmedthat significantly been patients,and the of IL-10couldinfluenceits wasto polymorphismsgene expression.Thepresentstudy whetherIL-IO havesomeassociationwiththe investigate genepolymorphism cachexia from with cancer. patientsgastric FromOctober Methods 2008to 2009.aUoftheconsecutivewith cancer May patientsgastric admittedtoour for treatmentwere considered.The hospitalsurgical prospectively weredividedinto2 tothe of loss the patients groupsaccordingseverityweightduring 6monthsandserumC-reactive at preceding protein(CRP)level loss1 CRP10 loss=10%. 0%plus mg/L;non-cachexia group,weight group,weight IL-IOlevelwas Theserum examined by analyzed the at and-592A/CintheIL-10 polymorphismspositions·1082A/G,·819T/C

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