基于信号放大技术的适体生物传感器的研究进展.pdf

生物技术通报 ·技术与方法· BIOTECHNOLOGY BULLETIN ( ) 2015, 31 1 :67-72 基于信号放大技术的适体生物传感器研究进展 1，2 1 1 1 2 薛茗月   覃英凤  李健  叶高杰  湛志华 （1. 广西师范大学化学与药学学院 药用资源化学与药物分子工程教育部重点实验室，桂林 541004 ； 2. 桂林师范高等专科学校，桂林 541001） 摘 要 ： 信号放大技术因其能实现低浓度分子检测，灵敏度高而在多个研究领域发展非常迅速。而适体作为识别分子已成 功应用于多种生物传感器平台，在医疗诊断、环境检测、生化分析中显示出良好的应用前景。近年来，以适体为识别元件的生物 传感器越来越受到人们的关注。综述了近3 年来基于信号放大技术的适体生物传感器研究新发展。 关键词 ： 信号放大技术 ；适体 ；生物传感器 DIO ： 10.13560/ki.biotech.bull.1985.2015.01.010 Advance Based on Signal Amplification Technology with Aptamer Biosensor 1，2 1 1 1 2 Xue Mingyue Qin Yingfeng Li Jian Ye Gaojie Zhan Zhihua （1. Key Laboratory for the Chemistry and Molecular Engineering of Medical Resources （Ministry of Education of China ），College of Chemistry and Pharmaceutical Sciences ，Guangxi Normal Univeisitv ，Guilin 541004 ；2. Guilin Normal College ，Guilin 541001 ） Abstract: Signal amplification technology has grown immensely in many fields because of its high accuracy and sensitivity at low concentrations. As a recognized molecule, aptamer has been used on many biosensors, and also has shown a good prospect in medical diagnosis, environmental monitoring and biological analysis. In recent years, biosensors with aptamer as recognized molecule has attracted more and more attention. The new research development of aptamer biosensors based on signal amplification technology in nearly three years was summarized especially. Key words: signal amplification technology ；aptamer ；biosensor 随着生物学研究领域的不断