抗病毒适体药物研析进展.pdfVIP

药学学报 Acta Pharmaceutica Sinica 20 13, 48 (4): 447 456 ·447 · ·综述· 抗病毒适体药物的研究进展 尧, 吕颖慧, 杨会勇, 林俊生, 王启钊* (华侨大学生物医学学院, 福建 泉州 362021) 摘要: 核酸适体具有靶分子范围广、亲和力高、特异性强等优点, 被广泛应用于检测诊断和药物研发等领域。 在抗病毒作用方面, 适体独特的空间结构和膜穿透能力, 不但可分别与病毒的胞膜、基因组、酶等病毒成分结合 而抑制病毒感染, 还可通过互相连接或与 siRNA 连接来共同实现抗病毒作用。本文主要以艾滋病病毒和丙型肝 炎病毒为例, 阐述适体在各个阶段阻止病毒入侵的作用机制及研究进展, 为开发新型抗病毒药物提供思路。 关键词: 适体; 病毒; 艾滋病病毒; 丙型肝炎病毒; 基因治疗 中图分类号: R978.1 文献标识码: A 文章编号: 0513-4870 (2013) 04-0447- 10 Recent progress of the aptamer-based antiviral drugs ZHU Yao, LÜ Ying-hui , YANG Hui-yong, LIN Jun-sheng, WANG Qi-zhao* (School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China ) Abstract : Aptamers are capable of binding a wide range of biomolecular targets with high affinity and specificity. It has been widely developed for diagnostic and therapeutic purposes. Because of unique three dimensional structures and cell-membrane penetration, aptamers inhibit virus infection not only through binding specific target, such as the viral envelope, genomic site, enzyme, or other viral components, but also can be connected to each other or with siRNA jo intly achieve antiviral activity. Taking human immunodeficiency virus and hepatitis C virus as examples, this paper reviewed the effects and mechanisms of aptamers on disturbing viral infection and replication steps. It may provide an insight to the development of aptamer-based new antiviral drugs. Key words: aptamer; virus; HIV; HCV; gene therapy 病毒性疾病如艾滋病和病毒性肝炎, 已成为严 HIV) 和丙型肝炎