MALARIA..pptVIP

2007-14-2 MALARIA Department of Infectious Diseases Third Affiliated Hospital Sun Yat-sen University Lin Yang ▲ A parasitic diseases caused by plasmodium species. ▲ Transmitted by the bite of infected female anopheline mosquitoes. ▲ Characterized by periodic paroxysm with shaking chills, high fever, heavy sweating. ▲ Anemia and splenomegaly in cases suffering from several attack of paroxysm. ▲ P. vivax and P.ovale-caused malaria often relapse. ▲ P.falcipraum-caused malaria often shows irregular fever, and may occur cerebral malaria. ? Be epidemic in 92 countries and area ?New cases of malaria a year: 300 to 500 millions ?About two millions cases die a year ?About one million children die of malaria a year ?In China: In 2000: 25,520 cases 42 cases died ■ Etiology ▲ Four species of plasmodium cause malaria in human. P. vivax, P. ovale. P. malariae P. falciparum Each species has its own morphologic, biologic, pathogenic, and clinical characteristics. ? P.vivax is the most common. ? P. falciparum--- the most strong pathogenicity causes the cerebral malaria, causes the chief mortality, presents the therapeutic problem of chloroquine resistance. ? Development of plasmodium in anopheles gametocytes in blood circulation of human female anopheles by bite, sexual reproduction: (gametocytes zygote ookinete oocyst containing sporoblasts infective sporozoite ) humans blood circulation by bite ? life cycle in RBC and periodic paroxysm Clinical periodic paroxysm depend on life cycle of plasmodium in erythrocytes . Different plasmodium, the length of life cycle in RBC is different, so the interval of periodic paroxysm is different.