ADRENOCORTICAL CANCER课件.pptVIP

ADRENOCORTICAL CANCER Introduce 1 per 1.7 million population less than 0.02% of all cancers 0.2% of all cancer deaths 79% of adrenal tumors were functional Nonfunctional tumors may become functional a peak incidence at less than 5 years and a second peak in the fourth and fifth decades Clinical Features Hormonally functional tumors are slightly more common in women nonfunctioning tumors are more frequent in men Clinical Syndromes Produced by Adrenocortical Cancer and Their Frequency Cushings Syndrome The characteristic endocrine abnormality is an increase of plasma 11-deoxycortisol