聚乙二醇干扰素α―2a注射液联合阿德福韦酯治疗低水平转氨酶慢性乙型肝炎的效果观察.docVIP

聚乙二醇干扰素α―2a注射液联合阿德福韦酯治疗低水平转氨酶慢性乙型肝炎的效果观察 　　【摘要】 目的：探讨低水平转氨酶慢性乙型肝炎的抗病毒疗效。方法：156例低水平转氨酶慢性乙型肝炎患者，随机分为e抗原阳性治疗组42例（A组）及对照组40例（B组），e抗原阴性治疗组36例（C组）及对照组38例（D组），治疗组给予派罗欣180 μg皮下注射1次/周，24周后联合阿德福韦酯10 mg 1次/d，48周后停用派罗欣单用阿德福韦酯；对照组给予阿德福韦酯10 mg 1次/d。两组均按2005年版《慢性乙型肝炎防治指南》标准停药。结果：e抗原阳性治疗组与对照组在治疗48、72周时HBV-DNA阴转率、e抗原血清学转换率、停药24周复发率比较差异均有统计学意义（P0.05），停药24周复发率比较差异有统计学意义（P中国论文网 /6/view-7153979.htm 　　【关键词】 慢性乙型肝炎； 干扰素α-2a； 阿德福韦酯； 抗病毒； 联合 　　Clinical Observation of Peginterferon α-2a Combined with Adefovir Dipivioxil Antivirus Treatment in Chronic Hepatitis B Patients with Low ALT Level/FAN Min，TU De-xing，SUN Wen-feng，et al.//Medical Innovation of China，2015，12（29）：045-048 　　【Abstract】 Objective： To investigate the effect of antivirus treatment in chronic hepatitis B （CHB） patients with low ALT level. Method： 156 CHB patients with low ALT level were equally randomly divided into 4 groups： the HBeAg（+） treatment group （group A）for 42 cases and the control group （group B）for 40 cases； the HBeAg（-） treatment group （group C）for 36 cases and the corresponding control group （group D）for 38 cases. The patients in the HBeAg（+） or HBeAg（-） treatment group were respectively given peginterferon α-2a（180 μg） once a week，after 24 weeks， these patients were added with Adefovir dipivioxil（10 mg） once a day ，after 48 weeks，Peginterferon α-2a was stoped and Adefovir dipivioxil was given continually to the patients.Two control groups were respectively given Adefovir dipivioxil（10 mg， once a day）， the stopping standand of antiviral drugs was according to the guideline of prevention and treatment for CHB in 2005，China.Result： The HBV-DNA conversion rates ，HBeAg conversion rates and the relapsing rate after stop of antivirus drugs for 24 weeks in group A were all significantly different from the group B（P0.05）， however， the relapsing rate after stop of antivirus drugs for 24 weeks in group C was significantly different from the group D（P 　　doi：10.3969/j.issn.1674-4985.2015.29.014 　　中国是乙肝大国，每年约有3000万人发病。乙肝