西咪替丁和干扰素联合补锌治疗小儿轮状病毒感染性腹泻的疗效和安全性.docVIP

西咪替丁和干扰素联合补锌治疗小儿轮状病毒感染性腹泻的疗效和安全性 　　【摘要】 目的 探讨西咪替丁和干扰素联合补锌治疗小儿轮状病毒感染性腹泻的疗效和安全性。方法 100例小儿轮状病毒感染性腹泻患儿， 随机分为对照组和观察组， 每组50例。对照组给予干扰素、西咪替丁治疗， 观察组在此基础上联合补锌治疗。观察两组治疗效果。结果 观察组治疗总有效率为94.0%， 明显高于对照组的78.0%， 差异有统计学意义（P0.05）。结论 在常规给予干扰素、西咪替丁治疗的基础上联合补锌治疗小儿轮状病毒感染性腹泻可收到满意效果， 有利于患儿早期恢复， 且用药安全性较高， 值得临床推广使用。 中国论文网 /6/view-7188686.htm 　　【关键词】 轮状病毒；西咪替丁；干扰素；腹泻；补锌；安全性 　　DOI：10.14163/ki.11-5547/r.2016.01.002 　　Curative effect and safety by cimetidine and interferon combined with zinc supplements in the treatment of pediatric rotavirus infected diarrhea LIANG Rong-wei. Department of Pediatrics， Dongguan Donghua Hospital， Dongguan 523110， China 　　【Abstract】 Objective To investigate curative effect and safety by cimetidine and interferon combined with zinc supplements in the treatment of pediatric rotavirus infected diarrhea. Methods A total of 100 children with pediatric rotavirus infected diarrhea were randomly divided into control group and observation group， with 50 cases in each group. The control group received interferon and cimetidine for treatment， and the observation group received additional zinc supplements for treatment. Their curative effects were observed. Results The observation group had much higher total effective rate as 94.0% than 78.0% of the control group， and their difference had statistical significance （P0.05）. Conclusion On the basis of conventional treatment by interferon and cimetidine， implement of zinc supplements in treating pediatric rotavirus infected diarrhea provides satisfactory effect. This method is helpful for early rehabilitation in children patients， along with high safety of drug use. It is worth clinical promotion and application. 　　【Key words】 Rotavirus； Cimetidine； Interferon； Diarrhea； Zinc supplements； Safety 　　在病毒感染性腹泻各类致病病原体中， 轮状病毒是其最为常见的一种， 多发于婴幼儿群体， 以秋冬季节最为盛行。临床对于本病发病确切机制仍不明确， 治疗标准也存在较大差异[1]。本文主要观察西咪替丁和干扰素联合补锌治疗小儿轮状病毒感染性腹泻的疗效和安全性。现报告如下。 　　1 资料与方法 　　1. 1 一般资料 选取2014年3月～2015年3月本院收治的100例小儿轮状病毒感染性腹泻患儿纳入本次研究， 所有患儿病情均经病原学检测[2]以及临床表现确诊。随机分为观