基层消化系统疾病详解.ppt

definition Peptic ulcers are caused by increased damaging and/or decreased protective defence factors. Acid and pepsin appear to be the most important factors in PU. Helicobacter pylori colonisation and/or non-steroidal anti-inflammatory drug (NSAID) use are also present in almost all PU patients. The most important defence factors have not been completely defined. Decreased duodenal bicarbonate and/or mucus production may contribute to the pathogenesis of PU. Moreover, it appears that locally produced growth factors are critical in the ulcer healing process. Soll AH. Pathogenesis o