硫辛酸和糖尿病西西糖尿病慢性并发症__2011__3.pptVIP

南京中医药大学附属医院 江苏省中西医结合医院 江苏省中医药研究院 A-DINNERDiabeticopathies Atheroscleropathy Diabetic cardiomyopathy/dermopathy Intimopathy/isletopathy Nephropathy Neuropathy Endotheliopathy Retinopathy 糖尿病治疗达标的概念 高血糖通过氧化应激导致慢性并发症 Association of free radicals, oxidative stress and disease ROS inflicts damage directly upon cellular macromolecules, ultimately leading to complications of diabetes Oxidative stress leads to complications of diabetes Potential areas of impact of oxidative stress in diabetes and the pre-diabetic state 2型糖尿病患者的氧化应激随血糖水平升高而增加 高血糖引起ROS增多的原因 葡萄糖的自氧化:高糖环境下的内皮细胞，可通过PKC依赖的NADPH氧化酶的