care__hf__companion__心脏再同步化治疗临床应用_COMPANION的研究和CARE__HF的研究.pptVIP

Use of cardiac resynchronization therapy (CRT) in COMPANION and CARE-HF Brief history Large group of patients in need of ICDs for primary prevention New era of biventricular pacing to improve HF symptoms COMPANION and CARE-HF Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure COMPANION COMPANION Design Parallel, randomized clinical trial in 1600 patients with moderate or severe heart failure with QRS 120 ms and PR interval 150 ms (Bristow MR et al. N Engl J Med 2004; 350: 2140-2150) Patients randomized in a 1:2:2 fashion to optimal medical therapy; optimal drug