NET的病理诊断天津精要.pptVIP

IHC can also test for CgA, which can be detected in the secretory granules of most NET. Similarly to the problem we have with detecting blood levels of CgA in NET of the distal colon and rectum, the IHC for CgA is not sensitive for the large bowel and appendix tumours that secrete CgB since the most commercially available CgA antibodies do not cross-react. ?Reference: Taupenot L, Harper KL, O’Connor DT. N Engl J Med. 2003;348:1134-1149. ? * In contrast to CgA, synaptophysin is expressed independently of secretory granules and therefore useful in identifying poorly granulated and poorly differ