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The locust genome provides insight into swarm formation and long-distance flight 蝗虫的基因组对集群和长途飞行提供了见解Locusts are one of the world’s most destructive agricultural pests and represent a useful model system in entomology. Here we present a draft 6.5 Gb genome sequence of Locusta migratoria, which is the largest animal genome sequenced so far. Our findings indicate that the large genome size of L. migratoriais likely to be because of transposable element proliferation combined with slow rates of loss for these elements. Methylome and transcriptome analyses reveal complex regulatory mechanisms involved in microtubule dynamic-mediated synapse plasticity during phase change. We find significant expansion of gene families associated with energy consumption and detoxification, consistent with long-distance flight capacity and phytophagy. We report hundreds of potential insecticide target genes, including cys-loop ligand-gated ion channels, G-protein-coupled receptors and lethal genes. The L. migratoria genome sequence offers new insights into the biology and sustainable management of this pest species, and will promote its wide use as a model system. 蝗虫是一个世界上最具破坏性的农业害虫,昆虫学代表一个有用的模系统。在这里，我们提出飞蝗6.5 Gb基因组序列的草案，这是迄今为止的动物基因组。我们的研究结果表明，的大基因组可能是因为转座子的。甲基化和转录组分析表明状态变化过程中涉及的微管动态介导突触可塑性复杂的机制。我们发现具有远距离飞行能力和植食性的能源消耗和解毒相关基因家族的显著扩张。我们潜在杀虫剂靶基因，包括配体门控离子通道， G蛋白偶联受体和致死基因。飞蝗基因组序列生物学和可持续管理提供了这种害虫物种的新的见解，并促进其作为一个模系统广泛使用。Since the dawn of agrarian civilization, locust plagues have been viewed as one of the most devastating natural disasters, linked with famine, strife and dissolution of societal order as documented in the Bible, the Qur’an and Chinese historical records 1,2. Unfortunately, locust plagues continue to cause destruction even today. For example, in 1988, locust swarms covered an enormous area of some 29 million square kilometres, extending over or into parts of up to 60 countries, resulting in billions of dollars in economic losses 3. The primary current method for combating locust ou