第五章_药物代谢080730技术分析.ppt

* * * * * * * * * * * * * * * * * * * * * * * * * * * * LOGO activity decreased 氯丙嗪→去甲氯丙嗪 LOGO activity increased 解热镇痛药非那西丁→对乙酰氨基酚 LOGO activation 左旋多巴酶解脱羧→多巴胺 LOGO toxicity 异烟肼→乙酰肼 C-N-NH 2 H O N N O H C-N-N H - C-CH 3 O N O C-OH + O H C-N-NH 2 CH 3 - Hepatotoxicity 肝毒性 Mutagenicity 致突变 Teratogenicity 致畸变 Carcinogenicity 致癌 LOGO O = C NH-CO NH-CO C CH 2 CH 3 CH 2 CH 2 CH CH 3 CH 3 CH 3 CH 3 CH 2 CH 2 C CH 2 CH 3 C NH-CO NH-CO O = C OH (异戊巴比妥)　　　　 　(羟化异戊巴比妥) Alkyl group ---- alcohol LOGO CH 3 SO 2 NHCONHC 4 H 9 [ O] SO 2 NHCONHC 4 H 9 CH 2 OH [ O ] SO 2 NHCONHC 4 H 9 CHO [ O ]