抗病毒治疗大幅提高慢乙重肝救治成功率介绍.doc

抗病毒治疗大幅提高慢乙重肝救治成功率介绍.doc

尊敬的作者您好: 此修改稿为排版前再修校对word稿,尚存在部分细节性意见见正文,请您逐条仔细修改,避免同一个问题反复修改。 请通览全文仔细查阅是否尚有其他修改之处或编辑修改不当,由于贵稿格式编辑已做修改部分内容已做更正请直接在本word版本上用不同颜色字体修改即可。 已按要求做了修改,用蓝色标示请审查。 王融冰 ·临床论著· 抗病毒治疗大幅提高慢性乙型重型肝炎救治成功率 ( 【摘要】目的 核苷类抗病毒治疗对慢性乙型重型肝炎救治成功率的影响,以便在临床中推广应用。方法 采用流行病学回顾性调查研究方法,将专科医院3个肝炎病区核苷类抗病毒药物投入临床使用的前期(1996~1998)、早期(2004~2006)普及期(2008~2010),个时段的救治成功有效率进行比较,同时对患者的性别、高发年龄平均住院数等进行分析。结果 随核苷类抗病毒的使用普及,慢性乙型重型肝炎的救治成功率大幅度提高,个时段成功率分别为38.0%、63.1%82.4%。观察时间段里以男性患者,男女患者数之比为4.1~4.4︰1,男女治疗无效之比~3.1:1。个时段患者年龄中位数分别是38.2岁、42.6岁40.6岁,以中青年为主。平均住院数逐步减少,个时段分别是40.4、37.326.1 d。外埠进京患者比例逐年增多,个时段分别是24.7%、33.0%45.2%。结论 核苷类抗病毒治疗显著提高了慢性乙型重型肝炎的救治成功率,节约了卫生资源。 【关键词慢性乙型重型肝炎核苷类物治疗成功率 ffect of nucleoside antiviral treatment on the success rate of patients with chronic severe hepatitis B WANG Rong-bing, WAN Gang, SUN Feng-xia, JIANG Yu-yong, ZHOU Gui-qin,WANG Xiao-jing,LIN Lian-sheng. (1 Beijing Ditan Hospital,Capital Medical University 2 Beijing University of Chinese Medicine) 参照本刊以往刊出文章格式添加英文部分的作者单位信息。 已修补 Corresponding author: WANG Xiao-jing, Email: n-y@ ,tjwsfyx@ 【Abstract】 Objective To investigate the influence of nucleoside antiviral treatment for the success rate of chronic severe hepatitis B and facilitate its clinical application. Methods Compared the success rate of chronic severe hepatitis B treatment of three stages by epidemiological retrospective investigation method: before nucleoside antiviral drug enters into clinical application (1996-1998), early phase of application (2004-2006), maturation stage of application (2008-2010). We also analyse sex ratio of patients, high-risk age and average hospitalization days. Results With the using and popularization of the nucleoside antiviral treatment , the success rate of chronic severe hepatitis B treatment was greatly improved, success rates of three stages were respectively 38.0%, 63.1% and 82.4%. During observation time, men still hold great majority, the sex ratio of man to female was 4.1-4.4︰1 , the inefficiency of man to female

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