干燥综合征患者外周血Th17、Treg和B细胞研究.pdf

一级亲属，与临床指标不相关，说明BAFF可能参与疾病的发生，但与疾病的严重 程度不平行。 活因子(BAFF)，流式细胞染色 4 stract Ab isallautoimmunediseasewithboth Background．PrimarySj69renssyndrome and affectsthe and organ-specificsystemicmanifestations．pSSsalivarylacrimal#ands also but involveotherexocrine ischaracterized may glands．It preferentiallyfrequently features：theformationof tissue．The byspecificpathological ectopic lymphoid mechanismisunclearandthereisnot either．Thl7and ofpSS anyspecifictherapies Treg are defined of Tcellandareconsideredcriticaltothe newly subgroupshelper ofautoimmunediseases．Bcell roleintheocculTenceof important development plays thereisstillfewerresearchesonthe ofThl and pSS．However expression7，Treg B a survivalfactorfor memorycell．B-lymphocyteactivatingfactor(BAFF)iskey B-cellsandensurestheirexistence clearance． throughreducingapoptotic Objective．To the ofC04+IL-17+Thl7cell，CD4+CD25+ investigateexpression T B the blood regulatory memorycell，in of with cells(Tregs)and peripheralpatients toexamineBAFFlevelin primarySj69ren’Ssyndrome(pSS)andhealthypeople．Then in and controls．Tothecorrelationsofthecellswithclinical pSS healthy