醚氨基及氨基酸的各种保护基及去保护方法大全.docVIP

醚、氨基及氨基酸的各种保护基及去保护方法大全 （整理有详细操作） [Acetate] [Benzoatel] [Pivaloate] [Levulinate] [Back to Carb. Synthesis] Ac - (acetate) ester  Standard Protection Procedure To a solution of the glycoside in dry pyridine (25 eq) under an inert atmosphere at room temperature, acetic anhydride (10 eq) is added and stirred until complete by TLC (usually 16 h).? The reaction mixture is then poured into ice/water and extracted three times with chloroform.? The combined organic layers are extracted with 3% HCl, saturated aqueous sodium bicarbonate, and water.? The organic layer is then dried and concentrated in v