阿尔茨海默病相关基因白细胞介素18(IL18)启动子区多态性对其转录活性影响.docVIP

【关键词】基因多态性； IL18 启动子；荧光素酶报告分析；阿尔茨海默病 The transcriptional activity of interleukin 18 gene ( IL18) promoter polymorphisms in Alzheimer’s disease abstract  Background:  Alzheimer’s disease is an neuronal degenerative  disorder that is mainly characterized by progressive dementia in the old.  Although etiology is not clear, numerous studies demonstrate  that  it  is related to the chronic inflammatory response in brain. As a inflammatory cytokine, IL18 has been confirmed to relate with AD. SNPS including －607C/A （RS1946518）、－137G/C（RS187238）exist in IL18 gene regulatory region. The relatio