神经系统退行性疾病基础PPT-神经生物学课件.pptVIP

Effects of GSK-3b on AD History of passive antibody therapy In the early 1890s, Behring and Kitasato found that injecting nonlethal doses of tetanus toxin into animals causes the animals blood to develop the ability to neutralize the toxin Inflammation and immune mechanisms in Alzheimer’s disease Adaptive Immunity Improve Ab clearance while avoiding inflammatory effect Microglia lacking E prostanoid receptor subtype 2 have enhanced Ab phagocytosis yet lack Ab-activated neurotoxicity Microglia can be neuroprotective by phagocytosing Ab; however, this comes at the cost of activated innate im