前交叉韧带重建的移植物选择说课.docx

本人水平有限，翻译不准之处，望各位指正，大家共同进步~Graft Selection for Anterior Cruciate Ligament Reconstruction：A Level I Systematic Review Comparing Failure Rates and Functional Outcomes前交叉韧带重建的移植物选择：一篇将失败率与功能性结局指标同时比较的Ⅰ级循证系统综述KEYWORDSAnterior cruciate ligament Bone-patellar tendon-bone composites Combined semitendinosus and gracilis hamstring tendons Revision关键词：前交叉韧带 骨-髌韧带-骨移植物 联合应用半腱肌和股四头肌腘绳肌腱 翻修Tear of the anterior cruciate ligament (ACL) is the most common ligamentous injury of the knee. Reconstructing this ligament is often required to restore functional stability of the knee.1,2 Despite the popularity of the procedure, the preferred graft remains controversial. Ideally, the graft should have similar characteristics as the native ACL. Regardless of graft type, the biologic and mechanical properties of the graft material should provide a favorable setting for early biologic incorporation, be amenable to secure fixation, and limit potential morbidity related to donor site. 前交叉韧带（ACL）撕裂是最常见的膝关节韧带损伤。韧带重建的目的就是要恢复膝关节的功能性稳定。尽管（重建）过程各异，但移植物的选择仍有争议。理想的移植物应该与天然ACL具有相似的特性。尽管移植物类型各异，但其生物学及力学特性都应该为（重建后的）早期生物学整合提供有利环境，有利于安全固定，并限制供体部位潜在的发病率。Many graft options are available for ACL reconstruction, including different autograft and allograft tissues. Autografts include bone-patellar tendon-bone composites (PT), combined semitendinosus and gracilis hamstring tendons (HT), and quadriceps tendon. Allograft options include the same types of tendons harvested from donors, in addition to Achilles and tibialis tendons. Tissue-engineered anterior cruciate grafts are not yet available for clinical use, but may become a feasible alternative in the future.ACL重建有多种移植物可供选择，包括自体组织移植物和异体组织移植物。自体移植物包括骨-髌韧带-骨移植物（PT）、联合应用半腱肌骨薄肌腘绳肌腱（HT）和股四头肌腱。除了跟腱和胫骨肌腱之外 ，还包括取自供者的相同类型的??腱。组织工程生产的ACL尚未用于临床，但其将来可能成为一种可行的ACL替代物。For the past few decades, PT autograft has been the gold standard for ACL reconstruction. Reasons for this include the strength of the tissue, relative ease of harvest, and bone-to-bone healing with