1 经典化疗药物biomarker课件.pptxVIP

经典化疗药物生物标志物;Right people Right time;常规化疗药物疗效预测分子靶向化疗;The ERCC1 (excision repair cross-complementing 1) is a gene encoding a protein of the nucleotide excision repair (NER) complex, a group of proteins able to correct DNA damage induced by substances forming adducts, like platinum (Martin et al, 2008). High levels of ERCC1 protein have been shown to be a positive prognostic factor in chemotherapy-naive radically resected NSCLC (Olaussen et al, 2006; Zheng et al, 2007; Simon et al, 2008). ;DNA损伤修复途径的靶点;DNA修复机制是铂类耐药的主要因素;DNA加合物与旁路调节;ERCC1;Olaussen KA, Dunant A, Fouret P, et al. N Engl J Med. 200