癫痫的治疗剖析.ppt

生物利用度 是指经过肝脏首过消除过程后，能被吸收进入机体体循环的药物相对量和速度。与药物的理化性质、剂型、给药途径及机体状态有关 * 药物消除速度是大多数AEDs作用时间的决定因素 * Anticonvulsants target ion channels and neurotransmitters that mediate the balance between neuronal excitation and inhibition1 Scharfman HE. The neurobiology of epilepsy. Curr Neurol Neurosci Rep. 2007;7:384-354. References for Chart [drug]: Rogawski MA, Bazil CW. New molecular targets for antiepileptic drugs: α2δ, SV2A, and Kv7/KCNQ/M potassium channels. Curr Neurol Neurosci Rep. 2008;8:345-352. [retigabine; brivaracetam] Rogawski MA. Diverse mechanisms of antiepileptic drugs in the development pipel