多孔淀粉作为淫羊藿总黄酮固体分散体载体的研究-中国中药杂志.doc

多孔淀粉作为淫羊藿总黄酮固体分散体载体的研究严红梅1,2，贾晓斌1,2(，张振海1(（.南京中医药大学，江苏 南京 210046.江苏省中医药研究院国家中医药管理局中药释药系统重点研究室，南京 210028；)摘要：评价多孔淀粉作为淫羊藿总黄酮固体分散体载体的特性。以多孔淀粉作为淫羊藿总黄酮固体分散体的载体淫羊藿苷为指标，淫羊藿总黄酮固体分散体与原料药体外溶出度的差异，采用扫描电镜法差示扫描量热法X射线粉末衍射法对淫羊藿总黄酮固体分散体进行物相表征。扫描电镜固体分散体淫羊藿总黄酮与多孔淀粉差示扫描量热法X射线粉末衍射法淫羊藿总黄酮与多孔淀粉比例为1:，显著增加淫羊藿苷的溶出速率。多孔淀粉作为中药固体分散体载体值得进一步研究。关键词：多孔淀粉；淫羊藿总黄酮；体外溶出度；物相表征 Study of Porous Starch as Total Flavonoids of Epimedium Solid Dispersion CarrierYAN Hong-mei1,2, JIA Xiao-bin1,2*, ZHANG Zhen-hai1,2*,SUN E1, XU Yi-hao2 (1. Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210046；2. Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Province, Nanjing 210028 ) Abstract: Objective:To evaluate the characteristic of porous starch (PS) as the carrier of the total flavonoids of Epimedium (TFE) solid dispersions. Methods: Using the PS as the carrier of TFE solid dispersions. The dissolution of icariin was selected as an indicator to analyze the differences of dissolution between TFE and its solid dispersion. TFE was characterized by scanning electron microscopy(SEM)，differential scanning calorimetry(DSC) and X-ray powder diffraction (XRD). Results: Solid dispersion was irregular block and no powder characteristics of TFE and PS could be seen in SEM. DSC and XRD analysis suggested that TFE may be present in solid dispersion as amorphous substance. The dissolution rate of icariin has been improved significantly when the proportion of TFE and PS was 1:2. PS as a traditional solid dispersion carrier is worthy of further study. Key Words: porous starch; total flavonoids of Epimedium; dissolution in vitro; physical characterization 淫羊藿总黄酮（total flavones of epimedium，TFE）为淫羊藿主要有效成分，对心血管、免疫系统、骨代谢及性机能等具有广泛的药理作用[1]，但其水溶性差，溶出速率低，了药效的发挥。 多孔淀粉(porous starch)，是指经人工方法处理而使颗粒呈现多孔状的淀粉，是一种由表及里形成具有孔洞结构的新型变性淀粉，具有较高的负载效率[6,7]。本实验淫羊藿总黄酮作为模型药物，以多孔淀粉作为载体，采用溶剂法，制成淫羊藿总黄酮多孔淀粉固体分散体，淫羊藿苷的体外溶出度，为多孔淀粉作为固体分散体载体提供理论和实践依据。 材料与仪器 DSC204差示扫描量热仪