《尿路炎症对膀胱肿瘤细胞学和FISH检测膀胱肿瘤结果的影响doc》.docVIP

尿路炎症对膀胱肿瘤细胞学和FISH检测的影响 徐述雄1,* 白晓峰1,* 朱建国1 石 华1 罗光恒1 刘 军1 王元林1 孙兆林1 冯 梅2, # （550002 贵阳，贵州省人民医院泌尿外科1，高压氧科2） [摘要] 目的方法2009年月至201年月FISH和膀胱镜等检查结果的155例比较尿路炎症对细胞学和FISH假阳性结果的影响。 结果结论Influence of Urinary Tract Inflammation on the cytology and fluorescence in situ hybridization for the Detection of Bladder Cancer Xu Shuxiong1, *, Bai Xiaofeng1，*,Zhu Jianguo1, Shi Hua1, Luo Guangheng1, Liu Jun1, Wang Yuanlin1, Sun Zhaolin1, Feng Mei2, # (1Department of Urology, 2Department of High Pressure Oxygen, Guizhou Provincial People’s Hospital, Guiyang, Guizhou province, 550002, China) [Abstract] Objective To evaluate the impact of urinary tract inflammation on cytology and fluorescence in situ hybridization (FISH) in hematuria patients, and provide a reasonable way to use cytology, FISH and cystoscopy for the detection of bladder cancer (BC). Methods From January 2009 to May 2013, patients with asymptomatic microscopic or gross hematuria who were suspicious for BC were enrolled in the study. Cytology, FISH and cystoscopy were performed. The presence of inflammation was evaluated by microscopy. False-positive results were compared with regard to the presence or absence of inflammation in patients. Results Of 155 patients, 74 (47.8%) had BC and 81 (52.2%) had no evidence of BC. A total of 37 patients (23.9%) had inflammation according to the defined criteria. The rate of inflammation in patients with BC was 21.6% versus 25.9% in patients without BC (P=0.530). False-positive cytology and FISH in patients without signs of inflammation were present in 14.8% and 16.7% of patients. In patients with inflammatory changes in the urine, false-positive result rates were 18.5% (P=0.669), and 25.9% (P=0.324). Conclusion Urinary tract inflammation did not impair the performance of cytology and FISH. Hence, patients with positive cytology and FISH results should undergo diagnostic cystoscopy, even in the case of concomitant urinary tract inflammation. [Key words] Urinary Tract Inflammation, cy