2 型糖尿病4 种疗方案的成本-效果分析[J].docVIP

2型糖尿病In Treatment Of Type 2 Diabetes Mellitus ShenWanxiang,Zhang Bangsheng(Department of pharmacy ,The Third Hospital Of Yin Chuan ,Yin Chuan 750004) ABSTRACT OBJECTIVE: To compare the economic effects of four trement schemes on type 2 diabetes . METHODS: Four trement schemes(Group A:Acarbose ; Group B :Glimepride、Group C Metformin、Group D：Repaglinide and Metformin of type 2 diabetes were compared by a cost-effect analysis method in pharmacoeconomics. RESULTS: The costs for Group A、B、 C and D were 798.32 yuan , 258.54 yuan,184.55yuan and 210.32yuan respectively; the total effective rates on blood-fasting sugar were 84.7%,83.3% ,81.7%and 87.3% respectively; the total effective rates on blood sugar 2 hours after meal were 94.4%,86.1%,85.9% and88.7% respectively; the cost-effectiveness ratio on blood-fasting sugar were 942.53, 310.37,225.89 and 240.92 respectively; the cost-effectiveness ratio on blood sugar 2 hours after meal were 845.68，300.28,214.84 and 237.11 respectively; the increments of cost-effectiveness ratios of group A 、B、 D on blood-fasting sugar were20459.00，4624.38 and 460.18 respectively as against group C; the increments of cost-effectiveness ratios of group A 、B、 D on blood sugar 2 hours after meal were 7220.82、36995.00 and 920.36 respectively as against group C. CONCLUSION: It is best to use Repaglinide and Metformin to control blood-fasting sugar level and blood sugar 2 hours after meal KEY WORDS: Type 2 diabetes mellitus; Acarbose, dimethyl biguanide, Repaglinide, Cost-effectiveness analysis 药物经济学在优化治疗方案,指导临床合理用药,提高经济效益,节约卫生资源,减轻病人经济负担,减少药物不良反应及降低药源性疾病等方面具有重要作用[１]。糖尿病是目前最常见的慢性病之一，到2009年，城市成年人糖尿病发病率已达9.7%a; B组 男性37例，女35例，平均年龄（53.5 (12.8）；C组；男性35例，女36例，平均年龄（50.9 (11.8）a; D组；男性36例，女35例，平均年龄（52.6 (13.5）a;四组2型糖尿病患者的性别、年龄、病程长短、体重、空腹血糖、餐后2h血糖及用药天数等经过统计学分析，p0.05,无显著性差异，具有可比性。 1.2 A组：阿卡波糖（德国拜尔，50mg×30片，2.66/片）；B组：格列美脲（贵州天安2mg×10片,1.554/片）；C组：二甲双胍（贵州天安0.25g×48片,0.336/片）；D组：瑞格列奈（江苏豪森0.5mg×30片，0.798/片）+二甲双胍（贵州天安0.25g×48片,0.336/片） 1.3 治疗方法： 所有病例均给予糖尿病饮食，给药方法：